Testosterone Restoration Therapy

Testosterone Restoration is NOT TRT.

Restoring your Natural Testosterone Levels

Restoring ones natural testosterone levels without Testosterone Therapy is not for everyone. But for those who qualify for this treatment, it is a way to increase your brain's signal to the testes telling them to increase testosterone production naturally.

How is this accomplished?

Selective Estrogen Receptor Modulators (SERMs) act as estrogen antagonists—they block estrogen from binding to the estrogen receptor in the brain, at the hypothalamus and the pituitary gland.

So when the brain thinks that it’s not getting enough estrogen, it stimulates the production of the hormones luteinizing hormone (LH) and Follicle Stimulating Hormone (FSH), which increases the testes production of testosterone and sperm, respectively. This stimulates your body into producing more of its own natural testosterone.

Testosterone Restoration Therapy

What is Enclomiphene?

Enclomiphene is the purified isomer of Clomid (Clomiphene Citrate), which has been FDA approved since 1967 for fertility in women, and has been commonly used off-label in men. Many research studies suggest Clomid “is safe and effective with few side effects when used as long-term treatment of hypogonadism (low testosterone) and is an “effective and safe alternative to testosterone supplementation in [young] men wishing to preserve their fertility”.

However, Clomid is actually made up of a mixture of two isomers: 38% zuclomiphene and 62% enclomiphene. Zuclomiphene is an estrogen receptor agonist (increases estrogen) that stays in your system a long time and accumulates much more over time than enclomiphene.

Clomid is believed to cause some minor side effects such as mood swings, depressed mood, irritability, anxiety, gynecomastia, and libido issues and ocular vessel swelling that can develop in a small percentage of patients over time.

"The literature has suggested that most of the beneficial effects of clomiphene are due to the trans-isomer enclomiphene. Zuclomiphene contributes little to the intended outcomes.“

What are potential side effects?

The adverse effects of Enclomiphene have been extensively studied during phase II and phase III clinical trials. The drug is generally well tolerated with side-effects occurring relatively rarely.

Headache(was observed in 3.3% of patients) Common Cold(was observed in 1.7% of patients)

Nausea(was observed in 2.1% of patients) Hot flush(was observed in 1.7% of patients)

Diarrhea(was observed in 1.9% of patients) Joint pain(was observed in 1.2% of patients)

Dizziness(was observed in 1% of patients)

  1. Earl JA, Kim ED. Enclomiphene citrate: A treatment that maintains fertility in men with secondary hypogonadism. Expert Rev Endocrinol Metab. 2019;14(3):157-65.

How can I determine if I am a candidate for Testosterone Restoration?

The experts at New England Low-T Center can analyze your condition through a simple bloodwork.

Therapy is as simple as a quick no cost consultation call, 2 electronic forms and a trip down to the lab.

Let us do the rest from there!

Call now to discuss this therapy and to arrange your labs.